LYMPHOID NEOPLASIA Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children’s Oncology Group Study
نویسندگان
چکیده
I-Ming Chen,1,2 Richard C. Harvey,1,2 Charles G. Mullighan,3 Julie Gastier-Foster,2,4,5 Walker Wharton,1 Huining Kang,1 Michael J. Borowitz,2,6 Bruce M. Camitta,2,7 Andrew J. Carroll,2,8 Meenakshi Devidas,2,9 D. Jeanette Pullen,2,10 Debbie Payne-Turner,3 Sarah K. Tasian,11 Shalini Reshmi,2,4,5 Catherine E. Cottrell,4 Gregory H. Reaman,2,12 W. Paul Bowman,2,13 William L. Carroll,2,14 Mignon L. Loh,2,15 Naomi J. Winick,2,16 Stephen P. Hunger,2,17 and Cheryl L. Willman1,2
منابع مشابه
Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study.
As controversy exists regarding the prognostic significance of genomic rearrangements of CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/intermediate-risk (SR) or high-risk (HR), we assessed the prognostic significance of CRLF2 mRNA expression, CRLF2 genomic lesions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated ...
متن کاملImproving outcomes for high-risk ALL: translating new discoveries into clinical care.
High-risk (HR) acute lymphoblastic leukemia (ALL) remains one of the greatest challenges in pediatric oncology. Relapsed ALL is a leading cause of death in young people, and further improvements in outcome will required the development of therapeutic approaches directed against rational therapeutic targets, as escalation of the intensity of existing therapies is limited by toxicity. This review...
متن کاملThe relation between end of induction minimal residual disease and different risk factors in patients with acute lymphoblastic leukemia
Background: Malignant disorder with B or T stem cell basis leads to development and continuation of acute lymphoblastic leukemia (ALL) due to aggregation of blast cells in bone marrow. The environmental, genetic, and demographic factors may influence the disease relapse. The objective of this study was to assess the relation between end of induction minimal residual disease and different risk f...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia
1University of New Mexico Cancer Center and Departments of Pathology and Internal Medicine, University of New Mexico, Albuquerque; 2Children’s Oncology Group, Arcadia, CA; 3Department of Pathology, St Jude Children’s Research Hospital, Memphis, TN; 4Department of Genetics, University of Alabama, Birmingham; 5Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN; 6Colleg...
متن کاملPediatric B Cell Acute Lymphoblastic Leukemia presenting with Paraneoplastic Acute Disseminated Encephalomyelitis
Acute Disseminated Encephalomyelitis (ADEM) is a monophasic demyelinating disease most often triggered by infection or immunization, though associations with malignancy and stem cell transplant have been described. We described the case of a four-year-old boy with new-onset neurological symptoms associated with ADEM, acute leukemia, and equivocal evidence of Mycoplasma pneumoniae infection. He ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012